NASDAQ : KPTI
Karyopharm Therapeutics Inc. — Financial statements
Healthcare · Biotechnology · United States
Last price 0.8798 USD (Oct 29, 2026, 4:00 PM EDT) · Market cap 19.96M
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Financial statements
Karyopharm Therapeutics Inc. (KPTI) reported revenue of 146.62M USD (TTM). Five years of income statement, balance sheet, cash flow and ratios below.
Income statement
Fiscal year January - December; amounts in USD.
| TTM | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 | |
|---|---|---|---|---|---|---|
| Revenue | 146.62M | 146.07M | 145.24M | 146.03M | 157.07M | 209.82M |
| Cost of Revenue | 1.38M | 5.95M | 6.01M | 4.94M | 5.21M | 3.40M |
| Gross Profit | 145.25M | 140.12M | 139.23M | 141.09M | 151.86M | 206.42M |
| Selling, General & Admin | 101.98M | 105.21M | 115.44M | 131.88M | 145.40M | 143.85M |
| Research & Development | 125.62M | 125.62M | 143.23M | 138.75M | 148.66M | 160.84M |
| Operating Expenses | 227.60M | 230.82M | 258.67M | 270.63M | 294.06M | 304.69M |
| Operating Income | -82.35M | -90.71M | -119.44M | -129.54M | -142.20M | -98.27M |
| Interest Expense | -49.32M | -45.85M | -37.42M | -23.82M | -25.00M | -26.05M |
| Interest & Investment Income | 2.39M | 2.77M | 7.40M | 10.94M | 2.36M | 582.00K |
| Other Non Operating Income (Expenses) | -33.13M | 152.00K | 28.40M | -356.00K | -83.00K | -85.00K |
| EBT Excluding Unusual Items | -162.41M | -133.63M | -121.07M | -142.78M | -164.92M | -123.82M |
| Other Unusual Items | -62.37M | -62.37M | 44.70M | |||
| Pretax Income | -224.77M | -196.00M | -76.36M | -142.78M | -164.92M | -123.82M |
| Income Tax Expense | -32.00K | 43.00K | 57.00K | 323.00K | 369.00K | 268.00K |
| Net Income | -224.74M | -196.04M | -76.42M | -143.10M | -165.29M | -124.09M |
| Net Income to Common | -224.74M | -196.04M | -76.42M | -143.10M | -165.29M | -124.09M |
| Shares Outstanding (Basic) | 19.41M | 10.94M | 8.12M | 7.62M | 5.46M | 5.01M |
| Shares Outstanding (Diluted) | 19.41M | 10.94M | 8.46M | 7.62M | 5.46M | 5.01M |
| EPS (Basic) | -11.58 | -17.93 | -9.41 | -18.79 | -30.28 | -24.75 |
| EPS (Diluted) | -11.58 | -17.93 | -14.00 | -18.79 | -30.30 | -24.75 |
| Free Cash Flow | -65.35M | -75.37M | -127.63M | -92.72M | -149.67M | -107.33M |
| Free Cash Flow Per Share | -3.37 | -6.89 | -15.10 | -12.18 | -27.42 | -21.40 |
| Gross Margin | 99.06% | 95.93% | 95.86% | 96.62% | 96.68% | 98.38% |
| Operating Margin | -56.16% | -62.10% | -82.24% | -88.71% | -90.53% | -46.84% |
| Profit Margin | -153.28% | -134.21% | -52.62% | -97.99% | -105.23% | -59.14% |
| Free Cash Flow Margin | -44.57% | -51.60% | -87.88% | -63.50% | -95.29% | -51.15% |
| EBITDA | -82.20M | -90.41M | -119.10M | -129.01M | -141.58M | -97.48M |
| EBITDA Margin | -56.06% | -61.90% | -82.01% | -88.34% | -90.14% | -46.46% |
| D&A For EBITDA | 149.00K | 296.00K | 340.00K | 530.00K | 621.00K | 789.00K |
| EBIT | -82.35M | -90.71M | -119.44M | -129.54M | -142.20M | -98.27M |
| EBIT Margin | -56.16% | -62.10% | -82.24% | -88.71% | -90.53% | -46.84% |
| Revenue as Reported | 146.62M | 146.07M | 145.24M | 146.03M | 157.07M | 209.82M |
Balance sheet
Fiscal year January - December; amounts in USD.
| TTM | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 | |
|---|---|---|---|---|---|---|
| Cash & Equivalents | 54.98M | 60.54M | 62.48M | 52.23M | 135.19M | 190.46M |
| Short-Term Investments | 10.12M | 3.20M | 46.24M | 139.21M | 142.78M | 38.16M |
| Cash & Short-Term Investments | 65.11M | 63.74M | 108.71M | 191.44M | 277.97M | 228.62M |
| Receivables | 29.87M | 26.18M | 30.77M | 27.96M | 54.89M | 23.90M |
| Inventory | 3.99M | 4.04M | 4.74M | 3.04M | 4.22M | 4.11M |
| Prepaid Expenses | 7.41M | 9.19M | 12.24M | 10.81M | 12.02M | 12.64M |
| Restricted Cash | 660.00K | 1.06M | 6.35M | |||
| Total Current Assets | 106.38M | 103.15M | 156.46M | 233.92M | 350.16M | 275.61M |
| Property, Plant & Equipment | 4.35M | 4.65M | 6.28M | 4.88M | 7.38M | 9.56M |
| Long-Term Accounts Receivable | 19.50M | |||||
| Other Long-Term Assets | 585.00K | 618.00K | 1.67M | 1.64M | 633.00K | 637.00K |
| Total Assets | 111.32M | 108.42M | 164.42M | 240.44M | 358.17M | 305.31M |
| Accounts Payable | 7.66M | 4.00M | 5.11M | 3.12M | 2.77M | 1.60M |
| Accrued Expenses | 78.80M | 64.50M | 60.65M | 61.39M | 58.41M | 69.12M |
| Short-Term Debt | 24.43M | |||||
| Current Portion of Long-Term Debt | 40.31M | 21.01M | ||||
| Current Portion of Leases | 1.07M | 969.00K | 438.00K | 3.31M | 2.87M | 2.32M |
| Other Current Liabilities | 6.39M | 1.58M | 1.64M | 1.65M | 1.85M | 678.00K |
| Total Current Liabilities | 134.23M | 92.06M | 92.26M | 69.48M | 65.91M | 73.72M |
| Long-Term Debt | 281.97M | 278.22M | 236.45M | 303.40M | 302.82M | 302.29M |
| Long-Term Leases | 5.18M | 5.74M | 6.71M | 2.79M | 6.10M | 8.97M |
| Other Long-Term Liabilities | 20.10M | 25.32M | 15.01M | 978.00K | ||
| Total Liabilities | 441.49M | 401.34M | 350.44M | 376.64M | 374.83M | 384.98M |
| Common Stock | 14.00K | 14.00K | 13.00K | 12.00K | 12.00K | 8.00K |
| Additional Paid-In Capital | 1.52B | 1.47B | 1.38B | 1.35B | 1.33B | 1.10B |
| Retained Earnings | -1.85B | -1.76B | -1.56B | -1.49B | -1.34B | -1.18B |
| Comprehensive Income & Other | 41.00K | 71.00K | -356.00K | -161.00K | -638.00K | 191.00K |
| Shareholders' Equity | -330.17M | -292.93M | -186.02M | -136.21M | -16.66M | -79.67M |
| Total Liabilities & Equity | 111.32M | 108.42M | 164.42M | 240.44M | 358.17M | 305.31M |
| Total Debt | 328.53M | 305.94M | 268.02M | 309.50M | 311.79M | 313.58M |
| Net Cash (Debt) | -263.43M | -242.20M | -159.31M | -118.05M | -33.83M | -84.96M |
| Net Cash Per Share | -13.57 | -22.15 | -18.84 | -15.50 | -6.20 | -16.94 |
| Filing Date Shares Outstanding | 22.68M | 18.34M | 8.42M | 7.67M | 7.56M | 5.28M |
| Total Common Shares Outstanding | 22.68M | 18.31M | 8.41M | 7.66M | 7.55M | 5.05M |
| Working Capital | -27.86M | 11.09M | 64.20M | 164.44M | 284.25M | 201.89M |
| Book Value Per Share | -14.56 | -16.00 | -22.11 | -17.78 | -2.21 | -15.78 |
| Tangible Book Value | -330.17M | -292.93M | -186.02M | -136.21M | -16.66M | -79.67M |
| Tangible Book Value Per Share | -14.56 | -16.00 | -22.11 | -17.78 | -2.21 | -15.78 |
| Machinery | 2.21M | 2.21M | 2.29M | 2.33M | 2.25M | |
| Leasehold Improvements | 3.40M | 4.88M | 4.88M | 5.45M | 5.45M |
Cash flow statement
Fiscal year January - December; amounts in USD.
| TTM | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 | |
|---|---|---|---|---|---|---|
| Net Income | -224.74M | -196.04M | -76.42M | -143.10M | -165.29M | -124.09M |
| Depreciation & Amortization | 149.00K | 296.00K | 340.00K | 530.00K | 621.00K | 789.00K |
| Other Amortization | 10.17M | 10.55M | 6.37M | 814.00K | 812.00K | 780.00K |
| Asset Writedown & Restructuring Costs | 7.36M | |||||
| Loss (Gain) From Sale of Investments | -142.00K | -410.00K | -2.50M | -4.10M | -825.00K | 1.56M |
| Stock-Based Compensation | 11.64M | 14.05M | 18.43M | 21.71M | 35.40M | 29.78M |
| Other Operating Activities | 112.70M | 67.92M | -73.39M | -281.00K | -106.00K | |
| Change in Accounts Receivable | 3.06M | 4.59M | -3.80M | 20.12M | -5.08M | -9.62M |
| Change in Inventory | 998.00K | 701.00K | -1.70M | 1.18M | -118.00K | -1.46M |
| Change in Accounts Payable | 5.06M | -1.10M | 1.98M | 350.00K | 1.17M | -2.85M |
| Change in Other Net Operating Assets | 15.75M | 24.09M | 3.21M | 9.77M | -15.96M | -9.26M |
| Operating Cash Flow | -65.35M | -75.37M | -127.49M | -92.72M | -149.55M | -107.12M |
| Capital Expenditures | -142.00K | -118.00K | -212.00K | |||
| Sale (Purchase) of Intangibles | -5.50M | |||||
| Investment in Securities | 2.97M | 43.38M | 95.61M | 7.94M | -104.14M | 147.55M |
| Investing Cash Flow | 2.97M | 43.38M | 95.47M | 7.94M | -104.26M | 141.84M |
| Long-Term Debt Issued | 27.25M | 83.30M | ||||
| Long-Term Debt Repaid | -250.00K | |||||
| Net Debt Issued (Repaid) | 27.00M | 27.00M | 83.30M | |||
| Issuance of Common Stock | 59.96M | 9.51M | 1.45M | 1.12M | 193.74M | 13.65M |
| Other Financing Activities | -8.37M | -6.46M | -43.11M | 60.00M | ||
| Financing Cash Flow | 78.60M | 30.05M | 41.65M | 1.12M | 193.74M | 73.65M |
| Foreign Exchange Rate Adjustments | 5.00K | 20.00K | -11.00K | -34.00K | -488.00K | -48.00K |
| Net Cash Flow | 16.22M | -1.92M | 9.62M | -83.69M | -60.56M | 108.32M |
| Free Cash Flow | -65.35M | -75.37M | -127.63M | -92.72M | -149.67M | -107.33M |
| Free Cash Flow Margin | -44.57% | -51.60% | -87.88% | -63.50% | -95.29% | -51.15% |
| Free Cash Flow Per Share | -3.37 | -6.89 | -15.10 | -12.18 | -27.42 | -21.40 |
| Levered Free Cash Flow | -29.67M | -49.43M | -77.09M | -39.95M | -101.35M | -58.64M |
| Unlevered Free Cash Flow | -9.02M | -31.32M | -60.07M | -25.87M | -86.54M | -43.14M |
| Cash Interest Paid | 14.38M | 38.59M | 21.23M | 34.45M | 15.54M | |
| Change in Working Capital | 24.87M | 28.27M | -302.00K | 31.42M | -19.99M | -23.19M |
Ratios
Fiscal year January - December; amounts in USD.
| TTM | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 | |
|---|---|---|---|---|---|---|
| Market Capitalization | 15.02M | 134.76M | 85.34M | 99.07M | 384.92M | 485.77M |
| Enterprise Value | 278.44M | 358.81M | 219.58M | 200.80M | 549.07M | 594.93M |
| Last Close Price | 0.66 | 7.36 | 10.14 | 12.97 | 51.00 | 96.45 |
| PS Ratio | 0.10 | 0.92 | 0.59 | 0.68 | 2.45 | 2.31 |
| PB Ratio | -0.46 | -0.46 | -0.73 | -23.11 | -6.10 | |
| EV/Sales Ratio | 1.90 | 2.46 | 1.51 | 1.38 | 3.50 | 2.83 |
| Debt / Equity Ratio | -0.99 | -1.04 | -1.44 | -2.27 | -18.72 | -3.94 |
| Net Debt / Equity Ratio | -0.80 | -0.83 | -0.86 | -0.87 | -2.03 | -1.07 |
| Net Debt / EBITDA Ratio | -3.21 | -2.68 | -1.34 | -0.92 | -0.24 | -0.87 |
| Net Debt / FCF Ratio | -4.03 | -3.21 | -1.25 | -1.27 | -0.23 | -0.79 |
| Asset Turnover | 1.36 | 1.07 | 0.72 | 0.49 | 0.47 | 0.68 |
| Inventory Turnover | 0.31 | 1.36 | 1.54 | 1.36 | 1.25 | 1.01 |
| Quick Ratio | 0.71 | 0.98 | 1.51 | 3.16 | 5.05 | 3.42 |
| Current Ratio | 0.79 | 1.12 | 1.70 | 3.37 | 5.31 | 3.74 |
| Return on Assets (ROA) | -47.61% | -41.56% | -36.88% | -27.05% | -26.79% | -19.86% |
| Return on Capital Employed (ROCE) | 359.40% | -554.60% | -165.50% | -75.80% | -48.70% | -42.40% |
| Earnings Yield | -1,749.47% | -145.47% | -89.55% | -144.44% | -42.94% | -25.55% |
| FCF Yield | -435.21% | -55.93% | -149.55% | -93.59% | -38.88% | -22.09% |
| Buyback Yield / Dilution | -129.56% | -29.33% | -11.02% | -39.54% | -8.85% | -4.41% |